NCT04184622 says 2539 people — where are the Week 72 outcomes?

I looked last month. The registry still only had enrollment and arms; no results tab. That doesn't mean the trial failed, just that posting can lag.

Lag how long though? Week 0-72 primary period ended, but some trials post results years later.

The 2539 number is what gets me. With four arms, that's a huge study. If outcomes were bad, they'd still be published somewhere.

Not necessarily. The record can be sparse because results are in a journal article instead of the registry.

I remember seeing registry entries where the results section stayed empty even after publication. The useful part here is the design: placebo vs 5, 10, and 15 mg over Week 0-Week 72. That makes it a dose-response question, not just a yes/no.

I'd want the actual Week 72 endpoint definitions before reading anything into the missing numbers.

Right, fasting glucose and A1c would tell very different stories. The snippet I saw didn't spell out the primary endpoint at all.

I asked a similar thing in a research thread and got told the results may be behind a conference abstract. Still haven't found it.

Week 72 is long for a placebo arm. Attrition alone can muddy the raw numbers, so maybe that's why the registry looks bare.

API issue? I checked the actual page, not just an app. No results section.

API issue wouldn't explain the page itself, though. What I've noticed with these GLP-1 registry entries is that the 'no results' thing isn't unusual early on.

NCT04184622 has 2539 people and that Week 0-72 window, so it's a big dataset. The doses are clearly listed as 5, 10, and 15 mg.

I wouldn't assume cover-up from an empty results tab. I'd rather see the statistical analysis plan and whether it was powered for a specific endpoint.

Without that, the 2539 figure is just a headcount.

The stats plan point is fair. But if the primary period is done, isn't there usually a results posting dealdine?

Trial sites usually post results a year or more after the last visit, so 72-week data sitting invisible for a wile is pretty normal.

Scale weight stalled for me nine straight weeks while my waist dropped another inch and a half — same food, same walking. I only caught it because I started logging a Sunday tape measure instead of trusting the morning number. If your glucose is flat but your belt notch moved, that's not nothing.

Nine months in I hit a wall so flat I went back and reread my own log like it was somebody else's. Every weekday was boring and identical — same breakfast, salad lunch, dinner at 6:30 — and the scale didn't budge from month 5 to month 8. What I wasn't tracking was Friday night through Sunday.

First time in years I added up a normal weekend and it was roughly 2,500 extra calories between takeout, two glasses of wine, and the 3pm cheese-and-cracker thing that isn't a meal but also isn't not a meal.

Trimming just the crackers and the second glass got me three pounds over eight weeks, which sounds tiny until you remember I'd spent three months getting zero. The other half was sleep.

I was averaging five and a half hours for a work thing, and my appetite on those days was a different animal — hungry by 10am, snacking by 3, resting heart rate up six beats. Nothing dramatic fixed it. I moved dinner 45 minutes earlier, put my phone in the kitchen, and walked 25 minutes after lunch instead of doomscrolling.

The plateau broke in about three weeks, slowly.

Not saying that's your situation, but if you're around 72 weeks and flat, the boring stuff I'd stopped doing was the boring stuff that had been working.

Mild disagreement: 'hidden' is doing a lot of work there. I've gone hunting for results on three different obesity trials and two were simply blank on the public record for close to two years after completion, then appeared all at once when the paper dropped. Annoying, not sinister.

Meanwhile what actually messed with my head around month 12 was water weight.

I had a five-day stretch where I was up 4.6 pounds on identical food and steps, and I nearly threw out my whole log over it — salty weekend, long flight, hormones, gone by day six, gone plus another pound. What saved me was a photo in the same mirror every two weeks in the same outfit.

At week 40 the scale said down 22 pounds and the phoos said I'd changed shape way more than that — shoulders back, waistband sitting flat, a shirt that used to pull across the chest hanging straight.

If your fasting and A1c numbers are just sitting there boring at this point, boring might be the win. The trial numbers will show up eventually; your own trend line is the one you can read this week.

Results tabs usually lag a year past completion, so I'd refresh the registry before assuming anything's buried.

Week 58 here: my spreadsheet shows 1.8 lb of movement across three months while my jeans went from a 38 waist to a 34, so the closet was telling a louder story than the scale. I measure waist and take one photo the first Sunday of each month, and the months I skip that ritual are exactly the ones where I convince myself nothing's changing.

Under six hours of sleep and my morning number jumps 2 lb like clockwork, and stress does the same thing to my appetite.

Honestly I'd stop framing week 72 as a finish line, since it's a report card for a trial, not for a Tuesday.

I run 12-week blocks now: one tape measure, one photo, a 20-minute walk after dinner, and I've logged more wins in six months of that than in a year of starig at weekly numbers. Are you tracking anything that isn't the scale?

I gave up refreshing trial pages and started measuring my waist on the first of the month instead.