Survodutide
Double agoniste GLP-1/glucagon en développement
Aperçu
Survodutide est un agoniste double des récepteurs du GLP-1 et du glucagon qui associe la suppression de l'appétit à l'oxydation directe des graisses.
Key Information
Mechanism
Double agonisme des récepteurs du GLP-1 (appétit) et du glucagon (oxydation des graisses, thermogenèse).
Benefits
- Jusqu'à 19 % de perte de poids
- Mécanisme double GLP-1/glucagon
- Oxydation des graisses + suppression de l'appétit
Side Effects
- Nausées
- Diarrhée
- Vomissements
Contraindications
- Not studied in pregnancy
Evidence Summary
La phase 2 a montré une perte de poids allant jusqu'à 19 % à 46 semaines. La phase 3 est en cours.
Research
La phase 2 a montré une perte de poids allant jusqu'à 19 % à 46 semaines.
View ResearchSafety
Effets secondaires gastro-intestinaux similaires à ceux de la classe GLP-1.
Frequently Asked Questions About Survodutide
What is Survodutide?
Survodutide is a research peptide also known as BI 456906. Double agoniste GLP-1/glucagon en développement It is studied for its potential therapeutic applications and is available from various research chemical vendors.
How does Survodutide work?
Double agonisme des récepteurs du GLP-1 (appétit) et du glucagon (oxydation des graisses, thermogenèse).
What is the recommended dosage for Survodutide?
The commonly studied dosage range for Survodutide is 0.6-4.8 mg weekly. Dosage protocols vary based on research objectives. Always consult published studies and start with conservative amounts. Survodutide should only be used in controlled research settings.
Where can I buy Survodutide?
PepsReview indexes Survodutide pricing from multiple vendors. Check the Vendors tab above for a price comparison table showing cost per milligram, purity, COA status, and stock availability. Vendor reviews from real users are available on each vendor's profile page.
Is Survodutide legal?
US regulatory status: Investigational (Phase 3). The legal status of Survodutide varies by jurisdiction. In most countries, it is sold as a research chemical, not for human consumption. Always verify the legal status in your country before purchasing.
What are the side effects of Survodutide?
Reported side effects include: Nausées, Diarrhée, Vomissements. Always review safety data and published studies before use.
Key Research Papers on Survodutide
The following peer-reviewed studies and clinical trials are indexed in our research library for Survodutide. Each paper links to a detailed summary with key findings, study design, and publication metadata.
- Glucagon and GLP-1 receptor dual agonist survodutide for obesity: a randomised, double-blind, placebo-controlled, dose-finding phase 2 trial — Lancet Diabetes Endocrinol, 2024 (300 citations)
- Survodutide Once Weekly for the Treatment of Adults with Obesity — N Engl J Med, 2026 (200 citations)
- Survodutide for the Treatment of Obesity: Rationale and Design of the SYNCHRONIZE Cardiovascular Outcomes Trial — JACC Heart Fail, 2024 (40 citations)
- Survodutide for treatment of obesity: Baseline characteristics of participants in a randomized, double-blind, placebo-controlled, phase 3 trial (SYNCHRONIZE™-1) — Diabetes Obes Metab, 2026 (10 citations)
- Baseline characteristics in the SYNCHRONIZE™-2 randomized phase 3 trial of survodutide, a glucagon receptor/GLP-1 receptor dual agonist, for obesity in people with type 2 diabetes — Diabetes Obes Metab, 2026 (10 citations)
Related Weight loss / Metabolic Peptides
Other peptides in the weight loss / metabolic category that may be of interest for comparative research:
No vendor prices yet
We don't have pricing data for this peptide yet.
Write a Review
Rating Breakdown
Based on 31 avis.
Avis
I’m 41, graphic designer, and picked survodutide mostly because it was the first injectable I heard about and could actually get. Didn’t really compare it to tirzepatide until after I started. I’m 14 weeks in: 0.6 mg for 4 weeks, then 1.2 mg, now 1.8 mg weekly. Down 16 lbs, appetite is way quieter, and I’m not raiding the kitchen at 10 pm. A1c went 5.5 to 5.1. First two days after each shot I get mild nausea and occasional sulfur burps, but nothing I can’t handle. If I were starting fresh I’d still research options, but I’m happy enough to stay on it.
I'm 47, a barber on my feet all day, and I've been on survodutide 12 weeks. Started 0.6 mg for 4 weeks, then 1.2 mg weekly. Down 19 lbs, 176 to 157, and my waist is 2.5 inches smaller. Appetite is much quieter; I eat smaller meals. Some nausea and tiredness for a few days after each dose increase, but I kept working. Liver enzymes dropped and A1c went 5.8 to 5.4. Losing weight shrinks deep belly and under-skin fat, plus some muscle, so I lift and eat protein. My belly and liver fat look better than with diet alone. Weekly shot is easy. Cost is the main downside.
I'm 50, retired mechanic. I went with survodutide mostly because it was the first peptide I actually figured out how to get. I didn't know tirz was easy to find until I'd already been injecting for a month. Anyway, 0.6 mg weekly for 4 weeks, then 1.2 mg. Ten weeks in, down 18 pounds. Appetite is cut hard, sometimes I forget lunch. First few days after each shot I get queasy and a little tired, but it passes. Blood sugar seems steadier. I wouldn't switch now. Just wish it was cheaper.
I'm 55 and sit at a desk all day. My oldest brought up survodutide, and I started digging into it. My wife and I both began at 2 mg weekly, moved to 4, 8, then 12 mg over about five months. I went from 231 to 214 lbs, lost 17 lbs, and my waist dropped 2 inches. Food noise and late-night snacking are way down. Fasting glucose went from 112 to 97, and my A1c slipped from 5.9 to 5.5. Blood pressure is a bit better too. Honestly, no real side effects, even at 12 mg—maybe one queasy morning. My wife had the same easy run. Weekly shot is simple.
52-year-old accountant, 5'10", started at 238 lbs. I did 0.6 mg weekly for 4 weeks, then 1.2 mg for 8 weeks. Down 19 lbs, waist went from 42 to 39 inches. Appetite was gone most days. Mild nausea first two weeks and some constipation. ALT dropped from 48 to 31. I know any weight loss cuts visceral fat, but the glucagon side seems to help liver and belly more than a plain GLP-1. Tesamorelin can target visceral fat in HIV lipodystrophy, but it doesn't cause weight loss, so survodutide did more overall. Would use again.
43yo accountant here. Started survodutide mainly for visceral fat and metabolic numbers. Ran 0.6mg weekly for 2 weeks, then 1.2mg, now on 1.8mg for 8 weeks. Down 14 lbs (213 to 199), waist 39 to 37, fasting glucose from 105 to 92. Appetite is way quieter, but not food-averse. Mild nausea and constipation early, gone by week 4. Back pain finally sorted, so I added resistance training and hiking again. The glucagon side seems to help belly fat. Still titrating slowly. Would recommend if you can handle the ramp.
47F paramedic here. I switched from tirzepatide to survodutide 0.6 mg weekly, then 2.4 mg by week 12. Stayed 16 weeks. Lost 21 lbs, about 10%, waist down 3 inches. Liver fat and visceral fat dropped, triglycerides fell 58 points, LDL 24, hs-CRP nearly half. BP down 7 points, A1c down 0.4. Appetite was quiet. Nausea first two weeks, fatigue, and my resting heart rate climbed 10 bpm. Kidneys looked better on labs. Cost is high and long-term safety still iffy, but for me the metabolic punch was worth it. I wanted the shinier option.
I started survodutide alone, no stack, because I was nervous about mixing stuff. Did 0.5 mg weekly for 4 weeks, then 1 mg for 8 weeks. Down 13 lbs and waist dropped about 1.75 inches. Not dramatic visceral fat magic, but my belt is looser and fasting glucose went from 102 to 94. Nausea first couple weeks, some constipation, nothing that stopped work. As a nurse I'm cautious, but this was manageable. If you want big visceral fat changes you might need higher dose or stack, but alone I got modest results.
43-year-old male nurse here, pretty green with peptides and never stacked anything. I ran survodutide solo for 10 weeks: 0.6 mg weekly for 4 weeks, then 1.2 mg, then 1.8 mg. Down 11 lbs, waist lost 1.5 inches, and my body-comp scale showed visceral fat dropping from 13 to 11 (not exact, but direction was clear). Appetite was way quieter, especially evenings. Mild nausea and constipation first 2-3 weeks, gone by week 6. No glycemic issues. I'd say yes, modest visceral loss is possible alone. Not dramatic, but solid.
I'm 50, retired mechanic. Started survodutide at 0.6 mg once a week, moved to 1.2 then 2.4 mg by week 12. Stayed there for 8 weeks. Down 18 lbs, belt two notches tighter. Appetite basically gone after week 3; I eat small meals and don't snack at night. Mild nausea first two weeks and some sulfur burps, but nothing that stopped work in the garage. Blood sugar looked steadier. I picked it because it was the first peptide I actually got my hands on, didn't know tirzepatide was easy to get then. I'd stick with it.
50-year-old PT here. Started survivodutide at 0.6 mg weekly, went up to 3.6 mg over 12 weeks, stayed there 5 months. Weight went 198 to 174, waist down 3 inches. Appetite didn't vanish, but I finally stopped grazing at night. Nausea hit me days 2-3 for the first month; ginger chews helped. Fasting glucose 108 to 92, BP a little better. I chose it first because it was the one I could actually get, and I don't regret it. Injection is easy once weekly. Energy better, joints happier. Not magic, but solid.
I’m 55, sell real estate, and had never heard of survodutide until my oldest son mentioned it. Started researching and my wife joined me. We titrated slowly over about six months, now at 12 mg weekly. I went from 242 to 211 lbs, so 31 down. Appetite is much quieter, I stop eating sooner, and my A1c fell from 6.1 to 5.6. My wife lost 24 lbs. Honestly no bad effects for either of us, not even nausea, right up to 12 mg. It’s pricey, but I feel better and clothes fit.
28M office job, started survodutide at 0.6 mg weekly for 4 weeks then 1.2 mg for 8 weeks. Down 18 lbs and body fat went from 29% to 24%, so about 5 points. Honestly at that higher BF, I stopped obsessing over whether it was visceral or subcutaneous; the mirror and bloodwork tell the story. Appetite was way quieter, maybe too quiet first few days. Mild nausea and some constipation, nothing that made me stop. A1c dropped 0.4 and triglycerides improved. Still get tired after shots. For the cost, I'd say it's worth it if you stick with it.
Started survodutide at 0.6 mg weekly back in March and crept up to 3.6 mg by July. Down 22 lbs (198 to 176) and my body fat went from 34% to 29% — wasn't chasing a number, but the mirror is noticeably different, and honestly at that much body fat I wasn't picky about which fat was leaving. Appetite is much quieter; I finish a plate and stop. Nausea after each dose bump for the first two weeks, plus some constipation I manage with magnesium. A1c 5.9 to 5.5, triglycerides finally dropped. Not cheap, and I'm writing a thesis, so calmer eating is worth a lot.
43M teacher. Started tirzepatide, then moved to survodutide 1.8 mg weekly for 5 months. Down 24 lbs (218 to 194), waist -3.5 in. ALT -35, triglycerides 210 to 130, LDL 142 to 98, hs-CRP 4.1 to 1.8, eGFR +5. BP 132/86 to 120/78. Appetite is very quiet. Nausea first few weeks, sulfur burps, resting HR up ~8 bpm. Cost hurts. Long-term safety still fuzzy. The fat/liver/kidney/cardio numbers beat tirz for me, but I feel more wired. I'd still stay on it.
I'm a 34-year-old personal trainer and was nervous to stack anything since I'm new to peptides. I ran Survodutide solo at 0.6 mg weekly for 8 weeks. Appetite dropped fast, but I could still eat enough to train. My weight went 151 to 144 lbs, and my waist measured 30.5 to 28.75 inches. InBody showed visceral fat area down from 92 to 84. Mild nausea and sulfur burps for the first 10 days, then fine. No stacking needed for me. It wasn't dramatic, but the visceral change was real. I'd use it again.
34, stay-at-home dad. Started survodutide at 0.8 mg weekly, moved to 2.4 mg over 8 weeks, stayed there for 4 months. Down 27 lbs, waist lost 3 inches. Triglycerides fell from 210 to 145, LDL dropped 28 points, liver fat scan improved, and BP went from 132/86 to 122/80. Appetite is way quieter, which helps me not snack while making the kids' meals. Nausea hit first two weeks, and my resting heart rate is up about 8 bpm. I switched from tirzepatide because I wanted the newest option. Results are solid, but cost and jittery feeling keep it from perfect.
I'm 31, used to turn wrenches before my back gave out. Ran survodutide for 18 weeks, started at 0.6 mg weekly and worked up to 2.4 mg. Appetite dropped hard by week 3. Down 19 lbs, body fat went from 36% to 30%, so about 6 points. My A1c fell 0.3 and triglycerides dropped 40 points. Nausea and sulfur burps hit me the first month, plus some tiredness, but they eased. If your body fat is higher, don't obsess over which fat is going first. A 5% body fat drop changes how you look and moves most labs in the right direction. Weekly shot is easy. Will keep going.
I started SURVODUTIDE after watching a close friend and her daughter use it—seeing their progress in person convinced me more than any chart. I also liked that it hits the glucagon receptor, which tirzepatide doesn’t, so it felt like a different tool. My doctor was cautious because tirzepatide is the familiar approved option, but we agreed to try. I began at 0.6 mg weekly for four weeks, then 1.2 mg. After 12 weeks I’m down 17 lbs (SW 184, CW 167). Appetite is much quieter, though I had nausea and sulfur burps weeks 2–4. Energy is stable. It’s not a miracle, but it’s working.
Ran survodutide for five months. Started at 0.6 mg weekly, went up to 3.6 mg. Nausea hit hard first two weeks, sulfur burps too, but faded. Appetite was gone, had to force protein. Lost 34 lbs, waist went from 40 to 35 inches. My A1c dropped from 5.7 to 5.2, liver enzymes normalized, and BP down 10 points. Definitely lost some arm muscle, so I lift now. Visceral fat seems way down, belly is flat-ish for first time. Weekly shot is easy. Not magic, still need diet, but it works.
55 y/o sales rep here. Started survodutide at 0.6 mg once weekly, then split to 0.6 mg twice weekly after four weeks because the glucagon side seemed to target my visceral fat. Ran it 10 weeks with my usual tirzepatide. Waist dropped 1.5 inches, weight 232 to 218, and a DEXA scan showed visceral fat down from 142 to 118 cm². Fasting glucose dropped about 10 points. Mild nausea and sulfur burps for two weeks, nothing bad. Appetite was quieter but not wiped out. Energy improved once my back rehab let me hike again. Would stay on it if cost was lower.
Participated in a trial. Lost 17% of body weight in 6 months. The glucagon component really helps with fat burning. Less nausea than pure GLP-1 agonists. Excited for approval.
I'm 47 and work as a physical therapist. My oldest brought up survodutide; I'd never heard of it, so I looked into it before starting. Titrated weekly from 0.5 mg to 12 mg over about 6 months. Down 31 lbs, from 228 to 197. Waist lost 3.5 inches. Appetite much quieter, and I finally stopped grazing at night. Wife used it too; both of us had zero bad effects all the way to 12 mg. Maybe mild nausea once or twice early on, nothing after. Energy in clinic is better, stairs easier. It's not cheap, but I'd do it again.
34 y/o paramedic here. Started survodutide mainly for the glucagon/visceral fat angle. Did 0.6 mg weekly for 4 weeks, then 1.2 mg, been on 1.8 mg for 6 weeks. Split into two shots to reduce sides. Down 14 lbs and about 1.5 inches off my waist; appetite is way quieter, but no magic. First few weeks had mild nausea and sulfur burps, now mostly constipation if I don't drink enough. Back issue is finally sorted, so I'm adding resistance training and hiking. Will keep going. Solid so far.
Been on survodutide for 3 months, down 16 lbs. The GLP-1/glucagon dual mechanism gives good fat oxidation. Appetite suppression is decent but not as strong as tirzepatide. Looking forward to more data.
I'm 45 and a teacher, so I need something that works without wrecking my day. Switched from tirzepatide to survodutide 12 weeks ago. Started at 1.5mg weekly, now at 3mg. Down 22 lbs, waist down 3 inches. Liver fat dropped a lot on my scan. Triglycerides went from 210 to 130, LDL 160 to 95, hs-CRP 4.2 to 1.8. BP better, eGFR improved. But resting heart rate up 10 bpm, nausea if I don't eat small meals. Cost is way higher. Long-term safety? No clue. But the extra fat loss and metabolic numbers are worth it.
50yo software dev here. I’m pretty new to this stuff and didn’t want to stack anything, so I ran survodutide solo. Started at 0.6 mg weekly for 2 weeks, then 1.2 mg for 6 weeks, then 1.8 mg for 8 weeks. Total 16 weeks. Lost about 11 lbs, and my waist dropped roughly 1.5 inches. Visceral fat wasn’t dramatic but definitely moving. Appetite was way quieter, which helped. Main sides: mild nausea first few days after shots and some constipation. No throwing up. Labs improved a bit, fasting glucose down maybe 6 points. Not a miracle, but solid for monotherapy.
I started survodutide 10 weeks ago, going from 0.6 mg up to 2.4 mg once a week. I'm down 14 lbs, my appetite is much quieter, and my waist feels looser. Weeks 1-3 brought mild nausea and sulfur burps, but that faded by week 5. I chose it because a coworker and her mom had visible results, and I liked the glucagon-receptor angle. Tirzepatide is more recognizable and easier to explain to a doctor, so I understand why some people stay with that. I'd pick survodutide again.
I’m 55 and work as an accountant, so sitting all day had my waist and liver numbers creeping up. Started survodutide at 0.6 mg weekly, moved to 1.8 mg by week 8. Down 14 lbs and 2.5 inches off my waist, with much less appetite after work. Mild nausea and constipation early on, so I split the weekly dose into two smaller shots and that helped. Fasting glucose and ALT improved. Back issue has paused heavy lifting, but I’m hiking three times a week again. Worth it if you can handle the titration.
I’m 28 and in grad school, started survodutide at 0.6 mg weekly and titrated to 2.4 mg over 12 weeks. Down 19 lbs, waist 3 inches, and my DEXA showed visceral fat fell a lot, though overall weight loss clearly did most of it. Appetite is way quieter. Nausea and constipation hit hard for the first 3 weeks, then eased; I still get some fatigue. Liver fat likely improved too, since my enzymes normalized. I haven’t used tesamorelin, but this seems better for visceral/liver because of the glucagon part. I’d continue if cost stays manageable.
I’m 52, retired mechanic, and never really took meds daily. I avoided stacking because I didn’t want surprises. I ran Survodutide alone: 0.6 mg weekly for 4 weeks, then 1.2 mg for 8 weeks. Down 14 lbs in 12 weeks. Waist went from 38 to 36 inches. Appetite dropped a lot, cravings mostly gone. Mild nausea first week or two, a little constipation, no vomiting. Energy was okay after I ate more protein. I still have a belly, but it’s softer and smaller. For a solo peptide, I’d call it modest but real. I’d do it again.
Community Discussions on Survodutide
Join the conversation in our peptide community forum. Real users share their survodutide experiences, dosing schedules, results, and tips.
View all Survodutide forum discussions