Completed Retatrutide Trials With No Posted Weight Data?

CTgov results lag is common. 445 in knee OA probably means pain and function scores, not just weight, and that takes time to clean.

Maybe. But NCT05548231 only had 32 people. A small completed trial with no topline feels less like cleanup and more like nobody is publishing.

The Phase 2 24.2% at 48 weeks was efficacy estimand, right? That's not the same as a real-world ITT number. The 28.7% company figure gets quoted without that caveat.

This is why I only trust peer-reviewed tables. Company Phase 3 numbers up to 28.7% are a headline, not a dataset. Show me full NCT05931367 results and I'll care.

I've watched CTgov for a while and the quiet ones are often trials where weight wasn't the primary endpoint. NCT05931367 was in knee OA, so the main readout may be pain and function scores.

NCT06039826 in postmenopausal women could have body composition or metabolic markers as endpoints. The Phase 2 24.2% at 48 weeks is still the cleanest obesity-specific number we have, even with estimand caveats.

The up-to-28.7% figure from four company-reported Phase 3 trials is interesting but not peer-reviewed, so I'd treat it as directional. The 445 and 46 enrollment numbers don't tell us when results were due.

Agreed on endpoints. Knee OA trials can live or die on pain and function, not scale weight.

Knee OA trials bury weight in the secondary outcomes, that's my read. Primary there is usually pain and function scores, so nobody's racing to publish a weight headline.

I've watched the results tab on a couple of these for months, and the auto-post window can stretch a year past completion, and small academic sites often just don't. Meanwhile I'm down 21 lbs in 14 weeks, waist 38 to 35, weighed Sunday mornings only.

Honestly a 32-person and a 46-person cohort just aren't powered for weight claims, so journals pass and the data sits in a drawer. I've got a friend in academic trials who says two years from completion to print is normal, conference late-breaker comes first.

The 445-person OA one is the only one that'd move anything, and I'd bet on an abstract before a paper.

Postmenopausal cohort of 46? That's a pilot wearing a trial's coat.

Meanwhile I stall for two weeks straight any time I sleep under six hours. Bodies make terrible endpoints.

I track waist at belly button every Sunday; a 445-person OA trial not posting weight data smells like a buried secondary endpoint.

I’ve been tracking daily since January: weight, waist at navel, and how my jeans fit on a 1–5 scale. Weeks 1–4 I dropped 5.2 lbs, weeks 5–7 were flat, then wek 8 I whooshed 4.8 lbs after a salty takeout weekend and a 12k-step Saturday. Weird part?

The whoosh followed higher carbs and a lazy Sunday, not a perfect diet week. So when a completed trial has no weight topline, I don’t automatically assume buried bad news; if the primary endpoint was knee pain or safety, weight might just be a table in the supplement. Still frustrating for people mapping this stuff.

Did anyone catch whether those entries have a results section pending versus just no posted data?

My scale les for three days after pizza, so I trust the jeans button more than any topline.

Weekends are my rel trial: Friday to Monday can undo four clean weekdays.

I worked on a site level for a bit and completion date is just the last visit, not database lock. We'd spend another 8-14 months querying and cleaning before anything went public, and that was for a simple diabetes registry.

Also the knee OA study may have pain/function as primary and weight as secondary, so even a topline might not lead with pounds.

ClinicalTrials.gov: where topline results go to nap indefinitely, and we refresh like it's a tracking number.

My n=1 data: under 6 hours of sleep, my morning weight jumps 1.8 lb and my hunger hits 8/10 by 2pm. Same food, same 8k steps, so it's not the scale being broken. If the topline omits sleep and stress, the weight number is still half the story. I'd take waist-to-height over a single kg change.

At this rate I'll hit goal before those results post.

I stopped trusting the scale as my only marker after my waist dropped 3.5 inches while my weight sat flat for seven weeks.

The tape kept moving even when the number didn't, which made me wonder if those OA trials care more about joint pain scores than pounds. Did the posted outcome measures list WOMAC or function as primary? That would explain a lot.